Lokelma(sodium zirconium cyclosilicate)
Lokelma (sodium zirconium cyclosilicate) is a small molecule pharmaceutical. Sodium zirconium cyclosilicate was first approved as Lokelma on 2018-03-22. It is used to treat hyperkalemia in the USA. It has been approved in Europe to treat hyperkalemia.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
Trade Name
FDA
EMA
Lokelma
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium zirconium cyclosilicate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOKELMA | AstraZeneca | N-207078 RX | 2018-05-18 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| lokelma | New Drug Application | 2024-02-08 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hyperkalemia | — | D006947 | E87.5 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
SODIUM ZIRCONIUM CYCLOSILICATE, LOKELMA, ASTRAZENECA | |||
| 2023-05-18 | NCE | ||
| 2023-04-24 | M-261 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Sodium Zirconium Cyclosilicate, Lokelma, Astrazeneca | |||
| 9592253 | 2035-10-14 | DP | U-2312 |
| 10300087 | 2035-10-14 | DP | U-2312 |
| 8877255 | 2033-10-22 | DP | |
| 9913860 | 2033-10-22 | DP | U-2312 |
| 10695365 | 2033-10-22 | DP | |
| 8802152 | 2032-04-19 | DP | |
| 8808750 | 2032-02-10 | U-2312 | |
| 9844567 | 2032-02-10 | U-2312 | |
| 9861658 | 2032-02-10 | U-2312 | |
| 10335432 | 2032-02-10 | U-2312 | |
| 10398730 | 2032-02-10 | U-2312 | |
| 10413569 | 2032-02-10 | DP | |
| 11406662 | 2032-02-10 | DP | |
HCPCS
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Clinical
Clinical Trials
40 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperkalemia | D006947 | — | E87.5 | 2 | 3 | 10 | 6 | 5 | 25 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | 2 | 2 | 3 | 7 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 1 | 2 | 3 | 6 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | 2 | — | 1 | 1 | 4 |
| Albuminuria | D000419 | EFO_0004285 | R80.9 | — | — | — | 1 | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | 1 | — | 1 |
| Diet therapy | D004035 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acidosis | D000138 | EFO_1000014 | E87.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sodium zirconium cyclosilicate |
| INN | — |
| Description | Sodium zirconium cyclosilicate, sold under the brand name Lokelma, is a medication used to treat high blood potassium. Onset of effects occurs in one to six hours. It is taken by mouth.
|
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 242800-27-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3301592 |
| ChEBI ID | — |
| PubChem CID | 91799284 |
| DrugBank | DB14048 |
| UNII ID | — |
Target
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Variants
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Financial
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Lokelma – AstraZeneca
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Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 766 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,186 adverse events reported
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